Drug EfficacyALKS2680's efficacy may be compromised by saturation of pharmacokinetics at approximately a 15mg dose, potentially limiting its treatment effectiveness.
Drug Safety And Side EffectsTAK-861's requirement for BID dosing and associated common side effects such as frequent urination and insomnia may affect its competitiveness in the market.
Regulatory ConcernsThe FDA's decision on the maximum exposure limit for ORX750, based on convulsions observed in a canine study, could raise concerns about the drug's safety profile.